Research Projects

Research is focused both on understanding the hair-cell mechanotransduction complex at an atomic level, and on developing gene therapies for hereditary deafness and blindness. These parallel programs share a number of approaches, methods and reagents. For both, we use a wide variety of methods, which include protein engineering, single molecule force spectroscopy, cryo-EM, site-directed mutagenesis, single-cell electrophysiology, immunohistochemistry, scanning and transmission electron microscopy, AAV vector development, behavioral and physiological testing of both vision and hearing, and therapeutic vector delivery to the inner ear and retina. We work on zebrafish, mouse, nonhuman primate and human organoid preparations. Some representative projects are described on the adjacent links.