Research Papers

(most recent first)

79. Lin, S-Y., Vollrath, M.A., Chae, S., Hopkins, N. and Corey, D.P. Pinball Wizard, a deafness and blindness gene in zebrafish, encodes a novel vesicle protein essential for synaptic transmission. (in review)


78. Christensen, A.P. and Corey, D.P. The outer pore and selectivity filter of TRPA1. (in review)


77. Karavitaki, K.D. and Corey, D.P. (2010) Sliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels. J. Neurosci. (in press)


76. Sotomayor, M., Weihofen, W.A., Gaudet, R. Corey, D.P. (2010) Structural determinants of cadherin-23 function in hearing and deafness. Neuron 66:85-100.


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75. Brierley, S.M, Hughes, P.A., Page, A.J., Kwan, K.Y., Martin, C.M., O'Donnell, T.A., Cooper, N.J., Harrington, A.M., Adam, B., Liebregts, T., Holtmann, G., Corey, D.P., Rychkov, G.Y. and Blackshaw, L.A. (2009) The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterol. 137:2084-2095.


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74. Tannous, B.A., Christensen, A.P., Pike, L., Wurdinger, T., Perry, K.F., Saydam, O., Jacobs, A.H., García-Añoveros, J., Weissleder, R., Sena-Esteves, M., Corey, D.P. and Breakefield, X.O. (2009) Mutant sodium channel for tumor therapy. Molecular Therapy 17:810-819.


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73. Kwan, K.Y., Glazer, J.M., Corey, D.P., Rice, F.L. and Stucky, C.L. (2009) TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci. 29:4808-4819.


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72. Macpherson, L.J., Xiao, B., Kwan, K.Y., Petrus, M.J., Dubin, A.E., Hwang, S., Cravatt, B., Corey, D.P. and Patapoutian, A. (2007) An ion channel essential for sensing chemical damage. J Neurosci. 27:11412-11415.


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71. Scheffer, D., Sage, C., Corey, D.P. and Pingault, V. (2007) Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. FEBS Letters 581:4651-4656.


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70. Scheffer, D., Sage, C., Plazas, P.V., Huang, M., Zhang, D-S., Chen, Z-Y., Elgoyhen, A.B., Corey, D.P. and Pingault, V. (2007) The a1 subunit of nicotinic acetylcholine receptors in the inner ear: Transcriptional regulation by ATOH1 and co-expression with the g subunit in hair cells. J. Neurochem 103: 2651-2664. >


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69. Sage, C., Huang, M., Vollrath, M.A., Brown, M.C., Hinds, P.W., Corey, D.P., Vetter, D.E. and Chen, Z-Y. (2006) Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl. Acad. Sci. USA 103:7345-7350.


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68. Kwan, K.Y, Allchorne, A.J., Vollrath, M.A., Christensen, A.P., Zhang, D-S., Woolf, C.J., Corey, D.P. (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-289.


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67. Kock, N., Naismith, T.V., Boston, H.E., Ozelius, L.J., Corey, D.P., Breakefield, X. O. and Hanson P.I (2006) Effects of genetic variations in the dystonia protein torsinA: Identification of polymorphism at residue 216 as protein modifier. Human Molecular Genetics 15:1355-1364.


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66. Cheung, E. L-M. and Corey, D.P. (2006). Ca2+ changes the force sensitivity of the hair-cell transduction channel. Biophysical Journal 90: 124-139.


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65. Sotomayor, M., Corey, D.P. and Schulten, K. (2005) In search of the hair-cell gating spring: Elastic properties of ankyrin and cadherin repeats. Structure 13: 669-682.


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64. Sage, C., Huang, M., Karimi, K., Gutierrez, G., Vollrath, M.A., Zhang, D-S., García-Añoveros, J., Hinds, P.W., Corwin, J.T., Corey, D.P. and Chen, Z-Y. (2005) Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science 307:1114-8


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63. Corey, D.P., Garcia-Anoveros, J., Holt, J.R., Kwan, K.Y., Lin, S-Y., Vollrath, M.A., Amalfitano, A., Cheung, E.L-M., Derfler, B.H., Duggan, A., Géléoc, G.S.G., Gray, P. A., Hoffman, M.P., Rehm, H.L., Tamasauskas, D., Zhang, D-S. (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432:723-30.


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62. Kamm, C., Boston, H., Hewett, J., Wilbur, J., Corey, D.P., Hanson, P.I., Ramesh, V., Breakefield, X.O. (2004) The early onset dystonia protein torsinA interacts with kinesin light chain 1. J Biol Chem. 279:19882-92.


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61. Liu, X.Z., Ouyang, X.M., Xia, X.J., Zheng, J., Pandya, A., Li, F. , Du, L.L., Welch,K.O., Petit, C., Smith, R.J.H., Webb, B.T., Yan, D., Arnos, K.S., Corey, D.P., Dallos, P., Nance W.E., Chen Z-Y. (2003) Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Human Molecular Genetics 12:1155-1162.


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60. Meyers, J.R., MacDonald, R.B., Duggan, A., Lenzi, D.P., Standaert, D.G., Corwin, J.T., and Corey, D.P. (2003) Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J. Neurosci. 23:4054–4065


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59. Rehm, H. L., Zhang, D-S., Brown, M. C., Burgess, B., Halpin, C., Berger, W., Morton, C. C., Corey, D.P. and Chen, Z-Y. (2002) Vascular system defects and sensorineural deafness in a mouse model of Norrie disease J. Neurosci. 22:4286-4292


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58. Holt, J. R., Gillespie, S. K. H., Provance, D. W., Shah, K., Shokat, K. M., Corey, D. P., Mercer, J. A. and Gillespie, P. G. (2002) A chemical-genetic strategy demonstrates myosin 1c mediates sensory adaptation in hair cells. Cell 108:371-381


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57. Chen, Z-Y. and Corey, D.P (2002) An inner ear gene expression database. J. Assoc. Res. Otolaryngol. 3:140-148.


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56. Duggan, A., García-Añoveros, J. and Corey D.P. (2001) The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of DRG neurons and dendrites of central neurons J. Biol. Chem. 277: 5203


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55. Gillespie, P.G., Albanesi, J.P., Bahler, M., Bement, W.M., Berg, J. S., Burgess, D.R., Burnside, B., Cheney, R.E., Corey, D.P., Coudrier, E., de Lanerolle, P., Hammer, J.A., Hasson, T., Holt, J.R., Hudspeth, A.J., Ikebe, M., Kendrick-Jones, J., Korn, E.D., Li, R., Mercer, J.A., Milligan, R.A., Mooseker, M.S., Ostap, E.M., Petit, C., Pollard, T.D., Sellers, J.R., Soldati, T. and Titus, M.A. (2001) Myosin-I nomenclature. J. Cell Biol. 155:703-704.


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54. Leung, J.C, Klein, C., Friedman, J., Vieregge, P., Jacobs, H., Doheny, D., Kamm, C., DeLeon, D., Pramstaller, P.P., Penney, J.B., Eisengart, M., Jankovic, J., Gasser, T., Bressman, S.B., Corey, D.P., Kramer, P., Brin, M.F., Ozelius, L.J. and Breakefield, X.O. (2001) Novel mutation in the TOR1A (DYT1) gene in atypical, early onset dystonia and polymorphisms in dystonia and early onset parkinsonism. Neurogenetics 3:133-143.


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53. García-Añoveros, J., Samad, T.A., Žuvela-Jelaska, L., Woolf, C.J., and Corey, D.P. (2001) Transport and localization of the DEG/ENaC ion channel BNaC1a to peripheral mechanosensory terminals of dorsal root ganglia neurons J. Neurosci. 21:2678-86.


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52. Chen, Z-Y., Hasson, T., Zhang, D-S., Schwender, B.J., Derfler, B.H., Mooseker, M.S. and Corey, D.P. (2001) Myosin VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Genomics 72:285-296.


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51. Berg, J.S., , Derfler, B.H., Pennisi, C.M., Corey, D.P. and Cheney, R. E. (2000) Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. J. Cell Sci. 113:3439-3451.


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50. Ozelius, L.J., Page, C.E., Klein, C., Hewett, J.W., Mineta, M., Leung, J., Shalish, C., Bressman, S.B., de Leon, D., Brin, M.F., Fahn, S., Corey, D.P. and Breakefield, X.O. (1999) The TOR1A (DYT1) gene family and its role in early onset torsion dystonia. Genomics 62:377-84.


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49. Liman, E.R., Corey, D.P. and Dulac, C. (1999) TRP2: A candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl. Acad. Sci. USA 96:5791-5796.


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48. Derby, M.L., Sena-Esteves, M., Breakefield, X.O., and Corey, D.P. (1999) Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors. Hearing Research 134:1-8.


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47. Holt, J.R., Johns, D.C., Wang, S., Chen, Z-Y., Dunn, R.J., Marban, E. and Corey, D.P. (1999) Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J. Neurophysiol. 81:1881-1888.

46. Garcia, J.A., Yee, A.G., Gillespie, P.G., and Corey, D.P. (1998) Localization of myosin-Ib near both ends of tip links in frog saccular hair cells. J. Neurosci. 18:8637-8647.


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45. García-Añoveros, J., García, J.A., Liu, J-D., and Corey, D.P. (1998) The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations. Neuron 20: 1231-1241.


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44. Holt, J.R., Corey, D.P. and Eatock, R.A. (1997) Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. J. Neurosci. 17:8739-8748.


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43. Ozelius, L.J., Hewett, J.W., Page, C.E., Bressman, S.B., Kramer, P.L., Shalish, C., de Leon, D., Brin, M.F., Raymond, D., Corey, D.P., Fahn, S., Risch, N.J., Buckler, A.J., Gusella, J.F., Breakefield, X.O. (1997) The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nature Genetics 17:40-48.


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42. Garcia-Anoveros,J., Derfler, B., Neville-Golden, J., Hyman, B.T. and Corey, D.P. (1997) BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U SA 94:1459-1464.


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41. Hasson, T., Gillespie, P.G., Garcia, J.A., MacDonald, R.B., Zhao, Y-d.,Yee, A.G., Mooseker, M.S. and Corey, D.P. (1997) Unconventional myosins in inner-ear sensory epithelia J. Cell Biol. 137:1287-1307.

40. Weston, M.D., Kelley, P.M., Overbeck, L.D., Wagenaar, M., Orten, D.J., Hasson, T., Chen, Z-Y., Corey, D.P., Mooseker, M., Sumegi, J., Cremers, C., Moller, C., Jacobsen, S.G., Gorin, M.B., and Kimberling, W.J. (1996) Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients. Am. J. Human Genetics 59:1074-1083.


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39. Kelley, P.M., Weston, M.D., Chen, Z-Y., Orten, D.J., Hasson, T., Overbeck, L.D., Pinnt, J., Talmadge, C., Ing, P., Mooseker, M.S., Corey, D.P., Sumegi, J. and Kimberling, W.J. (1997) The genomic structure of the gene defective in Usher syndrome type 1b (MYO7A). Genomics 40(1):73-79.


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38. Chen, Z-Y., Hasson, T., Kelley, P.M., Schwender, B.J., Schwartz, M.F., Ramakrishnan, M., Kimberling, W.J., Mooseker, M.S and Corey, D.P. (1996) Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B. Genomics 36:440-448.


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37. Hasson, T., Skowron, J.F., Gilbert, D.J., Avraham, K.B., Perry, W.L., Bement, W.M. Anderson, B.L., Sherr, E.H., Chen, Z-Y., Greene, L.A., Ward, D.C., Corey, D.P., Mooseker, M.S., Copeland, N.G., and Jenkins, N.A. (1996) Mapping of unconventional myosins in mouse and man. Genomics 36:431-439.


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36. Grosson, C.L.S., Cannon, S.C, Corey, D.P., and Gusella, J.F. (1996) Sequence of the voltage-gated sodium channel b1-subunit in wild-type and in quivering mice. Molecular Brain Research 42:222-226.


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35. Liman, E.R. and Corey, D.P. (1996) Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ. J. Neurosci. 16:4625-4637.


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34. Denk, W., Holt, J.R., Shepherd, G. M. G. and Corey, D.P. (1995) Localization of hair-cell transduction channels at both ends of tip links shown by imaging calcium in single stereocilia. Neuron 15:1311-1321.

33. Hasson, T., Heintzelman, M.B., Santos-Sacchi, J., Corey, D.P. and Mooseker, M.S. (1995) Expression in cochlea and retina of myosin-VIIa, the gene product defective in Usher syndrome type 1B. Proc. Natl. Acad. Sci. USA 92:9815-9819


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32. Chen, H., Thalmann, I., Adams, J.C., Avraham, K.B., Copeland, N.G., Jenkins, N.A., Beier, D.R., Corey, D.P., Thalmann, R., and Duyk, G.M. (1995) cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. Genomics 27:389-398.


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31. Solc, C.K., Derfler, B.H., Duyk, G.M. and Corey, D.P. (1994) Molecular cloning of myosins from the bullfrog saccular macula: A candidate for the adaptation motor. Auditory Neurosci 1:63-75.


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30. Shepherd, G.M.G. and Corey, D.P. (1994) The extent of adaptation in bullfrog saccular hair cells. J. Neurosci. 14:6217-6229.


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29. Corey, D.P. and Howard, J. (1994) Models for channel gating with compliant states. Biophys J. 66:1254-1257.


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28. Cannon, S.C., Brown, R.H. and Corey, D.P. (1993) Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels. Biophys J. 65:270-288.


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27. Cannon, S.C. and Corey, D.P. (1993) Loss of sodium channel inactivation by anemone toxin (ATX II) mimics the mytonic state in hyperkalemic periodic paralysis. J. Physiol. 466:501-520.


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26. Assad, J.A. and Corey, D.P. (1992) An active motor model for adaptation by vertebrate hair cells. J. Neurosci. 12:3291-3309.

25. Assad, J.A., Shepherd, G.M.G., and Corey, D.P. (1991) Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7:985-994.


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24. Cannon, S.C., Brown, R.H., and Corey, D.P. (1991) A sodium channel defect in hyperkalemic periodic paralysis: Potassium-induced failure of inactivation. Neuron 6:619-626.


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23. Shepherd, G.M.G., Corey, D.P., and Block, S.M. (1990) Actin cores of hair-cell stereocilia support myosin motility. Proc. Natl. Acad. Sci. USA 87:8627-8631.


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22. Barres, B.A., Koroshetz, W.J., Chun, L.L.Y., and Corey, D.P. (1990) Ion channel expression by white matter glia: The type-1 astrocyte. Neuron 5:527-544.


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21. Barres, B.A., Koroshetz, W.J., Swartz, K.J., Chun, L.L.Y., and Corey, D.P. (1990) Ion channel expression by white matter glia: The O-2A glial progenitor cell. Neuron 4:507-524.


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20. Barres, B.A, Chun, L.L.Y., and Corey, D.P. (1990) Reassessment of membrane properties in a classic glial preparation. In Differentiation and Functions of Glial Cells. Alan R. Liss, pp. 213-221.

19. Barres, B.A., Chun, L.L.Y., and Corey, D.P. (1989) Calcium current in cortical astrocytes: Induction by cAMP and neurotransmitters and permissive effect of serum factors. J.Neurosci. 9: 3169-3175.


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18. Barres, B.A., Chun, L.L.Y., and Corey, D.P. (1989) Glial and neuronal forms of the voltage-dependent sodium channel: Characteristics and cell-type distribution. Neuron 2: 1375-1388.


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17. Shepherd, G.M.G., Barres, B.A., and Corey, D.P. (1989) "Bundle blot" purification and initial protein characterization of hair-cell stereocilia. Proc. Natl. Acad. Sci. USA 86: 4973-4977.


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16. Assad, J.A., Hacohen, N., and Corey, D.P. (1989) Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. Proc. Natl. Acad. Sci. USA 86: 2918-2922.


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15. Hacohen, N., Assad, J.A., Smith, W.J., and Corey, D.P. (1989) Regulation of tension on hair-cell transduction channels: Displacement and calcium dependence. J. Neurosci. 9: 3988-3997.


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14. Barres, B.A., Silverstein, B.E., Corey, D.P., and Chun L.L.Y. (1988) Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron 1: 791-803.


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13. Barres, B.A., Chun, L.L.Y., and Corey, D.P. (1988) Ion channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes. Glia 1: 10-30.


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12. Eatock, R.A., Corey, D.P., and Hudspeth, A.J. (1987) Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus. J. Neurosci. 7:2821-2836.


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11. Weyler, W., Powell, J., Hsu, Y.-P.P., Chen, S., Corey, D.P., Utterback, M., Titlow, C., and Breakefield, X.O. (1987) Comparison of partial amino acid sequences deduced from the nucleotide sequence of a bovine adrenal monoamine oxidase cDNA clone to amino acid sequences obtained from bovine liver monoamine oxidase type B. Proceedings of the Ninth Symposium on Flavins and Flavoproteins. 725-728

10. Corey, D.P., Dubinsky, J.M., and Schwartz, E.A. (1984) The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina. J. Physiol. 354:557-575.


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9. Aldrich, R.W., Corey, D.P., and Stevens, C.F. (1983) A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306:436-441.


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8. Corey, D.P. and Stevens, C.F. (1983) Science and technology of patch-recording electrodes. In : Single-Channel Recording Eds. Bert Sakmann and Erwin Neher. Plenum Publishing Corp., New York. pp 53-68.

7. Corey, D.P. and Hudspeth, A.J. (1983) Kinetics of the receptor current in bullfrog saccular hair cells. J. Neurosci. 3:962-976.


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6. Corey, D.P. and Hudspeth, A.J. (1983) Analysis of the microphonic potential of the bullfrog's sacculus. J. Neurosci. 3:942-961.


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5. Corey, D.P. and Hudspeth, A.J. (1980) Mechanical stimulation and micromanipulation with piezoelectric bimorph elements. J. Neurosci. Methods 3:183-202.


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4. Corey, D.P. and Hudspeth, A.J. (1979) Ionic basis of the receptor potential in a vertebrate hair cell. Nature 281:675-677.


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3. Corey, D.P. and Hudspeth, A.J. (1979) Response latency of vertebrate hair cells. Biophys. J. 26:499-506.


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2. Hudspeth, A.J. and Corey, D.P. (1978) Controlled bending of high-resistance glass microelectrodes. Am. J. Physiol. 234:c56-57.


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1. Hudspeth, A.J. and Corey, D.P. (1977) Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc. Natl. Acad. Sci. USA 74:2407-2411.


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